Concept information
Preferred term
ADS
Definition
- [Adapted from "AUTOMATED DNA SEQUENCING", "http://www.p2000.umich.edu/chemical_waste/cw12.htm#Overview", by University of Michigan Occupational Safety and Environmental Health] In general, DNA sequencing involves determining the positions of labeled nucleotides that have been incorporated into a replicated piece of DNA. Traditionally, the nucleotides were labeled with radioactive isotopes and the sequnce read using autoradiography. The use of an automated DNA sequencer, however, negates the need for radioactive isotopes, and instead, uses a fluorescent dye to label the nucleotides. A laser stimulates the fluorescent dye, and then, the fluorescent emissions are collected on a charge coupled device that determines the wavelengths of those emissions. Each labeled nucleotide is distinguished by a different wavelenth. (en)
Broader concept
URI
https://gcmd.earthdata.nasa.gov/kms/concept/554a3c73-3b48-43ea-bf5b-8b98bc2b11bc
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