Concept information
Preferred term
RADAM
Definition
- Many of the mutagenic or lethal effects of ionizing radiation can be traced to structural and chemical modification of cellular DNA through double-strand breaks (DSB) and clustered lesions. Although the development of mechanistic models of radiation damage in DNA has reached a high level of sophistication, further refinements are needed to understand fully the underlying mechanisms in particular on a molecular level. The proposed studies are designed to provide, in a comprehensive manner, missing information about the molecular pathways that lead from initial deposition of radiative energy to the formation of double strand breaks and lesions in DNA. http://www.isa.au.dk/networks/cost/ (en)
Broader concept
- P - R (en)
URI
https://gcmd.earthdata.nasa.gov/kms/concept/bb34cd99-6123-4b14-8b95-73850ebb21f3
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